5.33657

PI4KIIIβ Inhibitor, BF738735

• Sinónimos: PI4KIIIβ Inhibitor, BF738735, 2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
• Fórmula empírica (notación de Hill): C₂₁H₁₉FN₄O₃S
• Número de CAS: 1436383-95-7
• Peso molecular: 426.46
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• Nivel de calidad: 100
• formulario: powder
• potencia: 5.7 nM IC₅₀
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: light gray
• solubilidad: DMSO: 50 mg/mL
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC₅₀ = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC₅₀ = 1.7 µM) and several other lipid kinases (IC₅₀ >10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC₅₀ = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
PI4KIII&beta

Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Strating, J.R.P.M., et al. 2015. Cell Reports.10, 600.
MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett.4, 585.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable