524618

PIP3 Antagonist, PITenin-7

The PIP3 Antagonist, PITenin-7 controls the biological activity of PIP3.

• Sinónimos: PIP3 Antagonist, PITenin-7, N-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7, Akt Inhibitor XX, PDK1 Inhibitor V
• Fórmula empírica (notación de Hill): C₂₂H₂₀N₂O₂S
• Número de CAS: 1356060-65-5
• Peso molecular: 376.47
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: semisolid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow-white
• solubilidad: DMSO: 100 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable DM-PIT-1 (Cat. No. 524619) analog that is more selective and potent than DM-PIT-1 against PH domain-mediated PIP3 (Cat. No. 524615) binding to Akt1 (IC₅₀ = 13.4 and 27.1 µM, respectively) and PDK1 (IC₅₀ = 52.3 and 80.5 µM, respectively), while being much less active than DM-PIT-1 against PIP3 GRP1 PH domain binding (12% vs 84% inhibition with 100 µM respective compound). PIT-7 is also shown to be more effective than DM-PIT-1 in inhibiting human glioblastoma U87MG survival (IC₅₀ = 6.6 vs. 33.9 µM, respectively) and cellular Akt Ser473 phosphorylation in cultures in vitro.

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Miao, B., et al. 2010. Proc. Natl. Acad. Sci. USA107, 20126.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable