512731

Paromomycin Sulfate

An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity.

• Sinónimos: Paromomycin Sulfate, Neomycin E
• Fórmula empírica (notación de Hill): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• Número de CAS: 1263-89-4
• Peso molecular: 615.63 (free base basis)
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: off-white
• solubilidad: water: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?;/m1./s1
• Clave InChI: LJRDOKAZOAKLDU-UMIPPVEZSA-N

Descripción

Descripción general

An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. Recent NMR evidence indicates paromomycin binding to the A-site of 16S rRNA induces a local conformational change that suggests a mechanism for aminoglycoside action on protein translation.

An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. Recent NMR evidence indicates that paromomycin binding to the A-site of 16S rRNA induces a local conformational change, suggesting a mechanism for aminoglycoside action on protein translation. Also exhibits anti-protozoal properties.

Potency: ≥675 µg/mg.

Advertencia

Toxicity: Harmful (C)

Otras notas

VanLoock, M.S., et al. 1999. J. Mol. Biol. 285, 2069.
Blanchard, S.C., et al. 1998. Biochemistry 37, 7716.
Fourmy, D., et al. 1998. J. Mol. Biol. 277, 333.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable