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Merck

P5057

Sigma-Aldrich

Paromomycin sulfate salt

powder, suitable for cell culture, BioReagent

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About This Item

Fórmula empírica (notación de Hill):
C23H45N5O14 · xH2SO4
Número de CAS:
Peso molecular:
615.63 (free base basis)
Beilstein:
5715182
Código UNSPSC:
12352207
ID de la sustancia en PubChem:
NACRES:
NA.76

product name

Paromomycin sulfate salt, powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg

Línea del producto

BioReagent

Nivel de calidad

formulario

powder

potencia

≥675 μg per mg

técnicas

cell culture | mammalian: suitable

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

Modo de acción

protein synthesis | interferes

cadena SMILES

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

Clave InChI

OYJABWUHUYVDMJ-UDXJMMFXSA-N

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Descripción general

Chemical structure: aminoglycoside
Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Aplicación

  • Paromomycin sulfate salt has been used as a:
  • reference compound in antileishmanial activity
  • RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.
Recommended for use in cell culture applications at 100mg/L.
Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

Acciones bioquímicas o fisiológicas

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

Otras notas

1g,5g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Paromomycin
Davidson RN, et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(7), 653-660 (2009)
Use of a non-adherent cell culture system for testing the effect of 2,3'-dideoxyinosine against Cryptosporidium parvum
Lawton P, et al.
FEMS Microbiology Letters, 176(1), 235-240 (1999)
Jair L Siqueira-Neto et al.
PLoS neglected tropical diseases, 4(5), e675-e675 (2010-05-11)
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic side effects and prohibitive costs commonly incompatible with patients from the tropical endemic countries. In this sense, there is an urgent need for new drugs as a treatment
Nanoarchitectures for Neglected Tropical Protozoal Diseases: Challenges and State of the Art
Nano- and Microscale Drug Delivery Systems, 439-480 (2017)
Antiparasitic Agents
Infectious Diseases, 2, 1345-1372 (2017)

Artículos

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

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