5.08228

L- Buthionine Sulfoximine

• Sinónimos: L- Buthionine Sulfoximine
• Fórmula empírica (notación de Hill): C₈H₁₈N₂O₃S
• Número de CAS: 83730-53-4
• Peso molecular: 222.31
• Número MDL: MFCD00067000
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥97% (TLC)
• Nivel de calidad: 100
• Formulario: powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: water: 50 mg/mL
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
• Clave InChI: KJQFBVYMGADDTQ-CVSPRKDYSA-N

Descripción

Descripción general

A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC₅₀ = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).

A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t_1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC₅₀ = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).

Acciones bioquímicas o fisiológicas

Primary Target
gamma-glutamylcysteine synthetase

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Fruehauf, J.P., et al. 1997. Pigment Cell Res.10, 236.
OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
Griffith, O. W., 1982. J. Biol. Chem.257, 13704.

Griffith, O. W., et al. 1979. J. Biol. Chem.254, 7558.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable