5.00667

Thiamine phosphoric acid ester chloride dihydrate

EMPROVE^® API

• Sinónimos: Thiamine monophosphate chloride dihydrate, [Thiaminium dihydrogen phosphate chloride (estersalt)], Aneurine monophosphate chloride
• Fórmula empírica (notación de Hill): C₁₂H₁₈ClN₄O₄PS · 2H₂O
• Número de CAS: 273724-21-3
• Peso molecular: 416.82
• Beilstein: 3844977
• Número MDL: MFCD00063473
• Código UNSPSC: 12352107
• Número índice de la CE: 208-536-9

Propiedades

• presión de vapor: <1 Pa ( 50 °C)
• Nivel de calidad: 600
• Línea del producto: EMPROVE^® API
• formulario: solid
• pH: 2-3 (20 °C, 100 g/L in H₂O)
• mp: 135 °C (decomposition)
• solubilidad: 176 g/L
• densidad: 1.53 g/cm³ at 20 °C
• densidad aparente: 670 kg/m³
• aplicaciones: liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• temp. de almacenamiento: 2-25°C
• cadena SMILES: [Cl-].Cc1ncc(C[n+]2csc(CCOP(O)(O)=O)c2C)c(N)n1
• InChI: 1S/C12H17N4O4PS.ClH/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H
• Clave InChI: GUGWNSHJDUEHNJ-UHFFFAOYSA-N

Descripción

Descripción general

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Thiamine phosphoric acid ester chloride dihydrate is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Thiamine phosphoric acid ester chloride dihydrate Emprove^® API is manufactured according to ICH Q7 guidelines. An ASMF is available.
This product is part of our proprietary Viscosity Reduction Platform and suitable for highly concentrated protein-based formulations.

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H317
• Consejos de prudencia: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Clasificaciones de peligro: Skin Sens. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable