481407
NF-κB Activation Inhibitor
InSolution, ≥98%
Sinónimos:
InSolution NF-κB Activation Inhibitor
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About This Item
Fórmula empírica (notación de Hill):
C22H20N4O
Peso molecular:
356.42
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
liquid
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
OK to freeze
desiccated (hygroscopic)
protect from light
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
Descripción general
A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.
Acciones bioquímicas o fisiológicas
Cell permeable: yes
Primary Target
NF-κB transcriptional activation
NF-κB transcriptional activation
Product does not compete with ATP.
Reversible: no
Target IC50: 11 nM against NF-κB transcriptional activation in Jurkat cells; 7 nM against LPS-induced TNF-α production in murine splenocytes
Envase
Packaged under inert gas
Advertencia
Toxicity: Toxic (F)
Forma física
A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.
Reconstitución
Following initial use, aliquot and refrigerate (4°C).
Otras notas
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Tobe, M., et al. 2003. Bioorg. Med. Chem.11, 383.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Punto de inflamabilidad (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificados de análisis (COA)
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Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.
Masanori Tobe et al.
Bioorganic & medicinal chemistry, 11(3), 383-391 (2003-01-09)
We disclose here a new structural class of low-molecular-weight inhibitors of NF-kappa B activation that were designed and synthesized by starting from quinazoline derivative 6a. Structure-activity relationship (SAR) studies based on 6a elucidated the structural requirements essential for the inhibitory
Fatmah A Mansour et al.
Oncoimmunology, 9(1), 1729299-1729299 (2020-04-22)
The T-cell inhibitory molecule PD-L1 is expressed on a fraction of breast cancer cells. The distribution of PD-L1 on the different subpopulations of breast cancer cells is not well-defined. Our aim was to study the expression level of PD-L1 on
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