654255

TNF-α Antagonist

≥95% (HPLC), lyophilized, TNF-α antagonist, Calbiochem^®

• Sinónimos: TNF-α Antagonist, TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
• Fórmula empírica (notación de Hill): C₅₈H₇₁N₁₁O₁₅S₂
• Peso molecular: 1226.38
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• product name: TNF-α Antagonist, The TNF-α Antagonist controls the biological activity of TNF-α.
• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: lyophilized
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• solubilidad: water: 1 mg/mL; 5% acetic acid: 5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 5 µM as TNF-α antagonist

Advertencia

Toxicity: Standard Handling (A)

Secuencia

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)

Otras notas

Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

Información legal

Sold under license of U.S. Patent 6,265,535.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable