445800

Merbarone

≥95% (HPLC), solid, topoisomerase II inhibitor, Calbiochem^®

• Sinónimos: Merbarone, 5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628
• Fórmula empírica (notación de Hill): C₁₁H₉N₃O₃S
• Número de CAS: 97534-21-9
• Peso molecular: 263.27
• Número MDL: MFCD00866337
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• product name: Merbarone, A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes.
• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: faint pink
• solubilidad: DMSO: 100 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18)
• Clave InChI: GFYRZTLCYQQVHZ-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 µM for purified mammalian topo II versus IC₅₀ = ~ 200 µM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

A cell-permeable, anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 µM for purified mammalian topoisomerase II versus IC₅₀ ~200 µM for topoisomerase I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Catalytic activity of topoisomerase II

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 20 µM for purified topoisomerase II (topo II)

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Khelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
Drake, F.H., et al. 1989. Cancer Res.49, 2578.
Brewer, A.D., et al. 1985. Biochem. Pharmacol.34, 2047.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable