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Merck
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Key Documents

444291

Sigma-Aldrich

MMP408

≥94% (HPLC), solid, MMP-12 inhibitor, Calbiochem®

Sinónimos:

MMP-12 Inhibitor, MMP408, (S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid

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About This Item

Fórmula empírica (notación de Hill):
C19H20N2O7S
Número de CAS:
1258003-93-8
Peso molecular:
420.44
Código UNSPSC:
12352200
NACRES:
NA.77

product name

MMP-12 Inhibitor, MMP408, The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Nivel de calidad

100

Análisis

≥94% (HPLC)

formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

off-white

solubilidad

DMSO: 100 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

Descripción general

A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM , respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Li, W., et al. 2009. J. Med. Chem.52, 1799.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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