371958

H-8, Dihydrochloride

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases.

• Sinónimos: H-8, Dihydrochloride, N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I
• Fórmula empírica (notación de Hill): C₁₂H₁₅N₃O₂S · 2HCl
• Número de CAS: 113276-94-1
• Peso molecular: 338.25
• Número MDL: MFCD00036962
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: >95% (TLC)
• Formulario: lyophilized
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• solubilidad: water: 10 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H
• Clave InChI: RJJLZYZEVNCZIW-UHFFFAOYSA-N

Descripción

Descripción general

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits protein kinase A (K_i = 1.2 µM), myosin light chain kinase (K_i = 68 µM), protein kinase C (K_i = 15 µM), and protein kinase G (K_i = 480 nM).

A potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (K_i = 68 µM), protein kinase A (K_i = 1.2 µM), protein kinase C (K_i = 15 µM), and protein kinase G (K_i = 480 nM).

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target K_i: 68 µM against MLCK

Advertencia

Toxicity: Standard Handling (A)

Nota de preparación

Further dilute with aqueous buffer just prior to use.

Otras notas

Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577.
Hidaka, H., et al. 1984. Biochemistry23, 5036.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable