371708

Gβγ Modulator II, Gallein

A cell-permeable xanthene compound that binds to Gβγ with high affinity (K_d ~400 nM derived from a surface plasma resonance binding study using Gβ1γ2) and blocks Gβγ-dependent cellular activities.

• Sinónimos: Gβγ Modulator II, Gallein, 4,5-Dihydroxyfluorescein, dihydrate, 2-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)-benzoic acid, dihydrate
• Fórmula empírica (notación de Hill): C₂₀H₁₂O₇ · 2H₂O
• Número de CAS: 2103-64-2
• Peso molecular: 400.34
• Código UNSPSC: 12171500
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥90% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: burgundy
• solubilidad: DMSO: 10 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C20H12O7/c21-13-7-5-11-17(15(13)23)26-18-12(6-8-14(22)16(18)24)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,21-24H
• Clave InChI: PHLYOKFVXIVOJC-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable xanthene compound that binds to Gβγ with high affinity (K_d ~400 nM derived from a surface plasma resonance binding study using Gβ₁γ₂) and blocks Gβγ-dependent cellular activities. Reported to exhibit in vivo prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model via either intraperitoneal or oral administration.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Lehmann, D.M., et al. 2008. Mol. Pharmacol.73, 410.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable