309795

DIDS disodium salt

≥85% (HPLC), solid, anion transport inhibitor, Calbiochem^®

• Sinónimos: DIDS, Disodium Salt, 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
• Fórmula empírica (notación de Hill): C₁₆H₈N₂O₆S₄ · 2Na
• Número de CAS: 53005-05-3
• Peso molecular: 498.48
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• product name: DIDS, Disodium Salt, Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.
• Nivel de calidad: 100
• Análisis: ≥85% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated; protect from light
• color: yellow
• solubilidad: water: 0.5%
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
• Clave InChI: YSCNMFDFYJUPEF-OWOJBTEDSA-N

Descripción

Descripción general

Binds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl^- uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has antiulcerous activity.

Binds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl^– uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Cl- uptake

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 150 nM inhibiting Cl- uptake in neuroblastoma cells

Advertencia

Toxicity: Irritant (B)

Otras notas

Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable