288500-M

DL-α-Difluoromethylornithine, Hydrochloride

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis.

• Sinónimos: DL-α-Difluoromethylornithine, Hydrochloride, DFMO, Eflornithine, RMI-71782
• Fórmula empírica (notación de Hill): C₆H₁₂F₂N₂O₂ · xHCl · yH₂O
• Número de CAS: 96020-91-6
• Peso molecular: 182.17 (anhydrous free base basis)
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥99% (TLC)
• Formulario: powder
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 1 mg/mL; methanol: 25 mg/mL
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
• Clave InChI: FJPAMFNRCFEGSD-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Acciones bioquímicas o fisiológicas

Primary Target
ODC

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitución

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Meyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
Takigawa, M., et al. 1990. Cancer Res.50, 4131.
Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
Danzin, C., et al. 1979. Life Sci. 24, 519.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable