287840

Diclofenac Sodium

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

• Sinónimos: Diclofenac Sodium, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
• Fórmula empírica (notación de Hill): C₁₄H₁₀Cl₂NO₂ · Na
• Número de CAS: 15307-79-6
• Peso molecular: 318.13
• Número MDL: MFCD00082251
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (TLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 25 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
• Clave InChI: KPHWPUGNDIVLNH-UHFFFAOYSA-M

Descripción

Descripción general

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC₅₀ = 9.5 µM).

A potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC₅₀ = 76 nM) and COX-2 (IC₅₀ = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC₅₀ ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
COX-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity

Advertencia

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitución

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
Merlos, M., et al. 1996. Inflamm. Res.45, 20.
Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H301 - H361d - H372 - H411
• Consejos de prudencia: P202 - P260 - P264 - P273 - P280 - P301 + P310
• Clasificaciones de peligro: Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable