218775

Castanospermine, Castanospermum australe

Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins.

• Sinónimos: Castanospermine, Castanospermum australe, (1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine
• Fórmula empírica (notación de Hill): C₈H₁₅NO₄
• Número de CAS: 79831-76-8
• Peso molecular: 189.21
• Número MDL: MFCD00017555
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (TLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4-,5-,6+,7+,8+/m0/s1
• Clave InChI: JDVVGAQPNNXQDW-TVNFTVLESA-N

Descripción

Descripción general

Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu₃Man_7-9 (GlcNAc)₂. Inhibits endothelial cell angiogenesis and tumor growth. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.

Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu₃Man_7-9(GlcNAc)₂. Reduces bFGF induced angiogenesis in mice. Inhibits endothelial cell migration and invasion of basement membrane. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
β-glucosidases

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Harmful (C)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Ahmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.
Pili, R., et al. 1995. Cancer Res.55, 2920.
Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA84, 8120.
Pan, Y.T., et al. 1983. Biochemistry22, 3975.
Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable