218708

Casein Kinase II Inhibitor I

InSolution

• Sinónimos: InSolution Casein Kinase II Inhibitor I
• Fórmula empírica (notación de Hill): C₆HBr₄N₃
• Peso molecular: 434.71
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC₅₀ = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC₅₀<1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC₅₀ = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC₅₀ = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
CK2 rat liver, human recombinant

Product competes with ATP.

Reversible: yes

Target IC₅₀: 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively

Envase

Packaged under inert gas

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Forma física

A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.

Reconstitución

Following initial use, aliquot and refrigerate (4°C).

Nota de análisis

Single spot by TLC

Otras notas

Borowski, P., et al. 2003. Eur. J. Biochem.270, 1645.
Zien, P., et al. 2003. Biochem. Biophys. Res. Commun.306, 129.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Sarno, S., et al. 2001. FEBS Lett.496, 44.
Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun.208, 418."

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 188.6 °F - (Dimethylsulfoxide)
• Punto de inflamabilidad (°C): 87 °C - (Dimethylsulfoxide)