203732

Brevetoxin PbTx-2

from Ptychodiscus brevis, ≥95% (HPLC), solid, Na+ channel-binding neurotoxin, Calbiochem^®

• Sinónimos: Brevetoxin PbTx-2, Ptychodiscus brevis, Brevetoxin B, GbTx-2
• Fórmula empírica (notación de Hill): C₅₀H₇₀O₁₄
• Número de CAS: 79580-28-2
• Peso molecular: 895.08
• Código UNSPSC: 51111800
• NACRES: NA.77

Propiedades

• product name: Brevetoxin PbTx-2, Ptychodiscus brevis, Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes.
• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: tan to white
• solubilidad: ethyl acetate: soluble; methanol: soluble; water: soluble
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• InChI: 1S/C50H70O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,24,26,28-42,44-45,52H,1,11-15,17-23H2,2-8H3/b10-9-
• Clave InChI: LYTCVQQGCSNFJU-KTKRTIGZSA-N

Descripción

Descripción general

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na⁺ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.

Lipid-soluble polyether neurotoxin that binds to Na⁺ channels on nerves and muscles causing an excessive influx of Na⁺ across membranes. Binds at site 5 on the voltage-sensitive Na⁺ channel.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Neurotoxin that binds to Na+ channels on nerves and muscles.

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

yes

Advertencia

Toxicity: Highly Toxic (H)

Reconstitución

Following reconstitution, aliquot, purge with iniert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.





From Catalog:

Solubitlity- removed acetone, EtOAc

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Edwards, R.A., et al. 1992. Mol. Brain Res.14, 64.
Trainer, V.L. 1991. Mol. Pharmacol.40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol.103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series418, 166.
Baden, G. 1989. FASEB J.3, 1807.
Baden, D.G., et al. 1988. Toxicon26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol.30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc.108, 514.
Nakanishi, K. 1985. Toxicon23, 473.
Baden, D.G., et al. 1982. Toxicon19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol.19, 345.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330
• Consejos de prudencia: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Clasificaciones de peligro: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable