200488

Bestatin Hydrochloride

InSolution, ≥98%, a metalloprotease inhibitor

• Sinónimos: InSolutionBestatin, Hydrochloride, [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu, HCl
• Fórmula empírica (notación de Hill): C₁₆H₂₄N₂O₄ · xHCl
• Peso molecular: 308.37 (free base basis)
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O.[xHCl]

Descripción

Descripción general

A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Metalloproteases

Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Forma física

Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.

Reconstitución

Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Otras notas

Merck Index: 14, 9842.
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable