14-902-M

AMPK (α2, β1, γ1) Protein, active, 10 µg

Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.

• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propiedades

• origen biológico: human
• Nivel de calidad: 100
• recombinante: expressed in E. coli
• Línea del producto: Upstate^®
• actividad específica: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• mol peso: M_w 30 kDa (AMPKß1); M_w 38 kDa (AMPKγ1); M_w 63 kDa (AMPKα2)
• purificado por: (Ni²⁺/NTA-agarose)
• reactividad de especies: human
• fabricante / nombre comercial: Upstate^®
• técnicas: activity assay: suitable (kinase)
• nº de acceso: (Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. ); NM_006252
• Nº de acceso NCBI: NM_002733; NM_006252; NM_006253
• Nº de acceso UniProt: P54619; P54646; P54646, Q9Y478, P54619; Q9Y478
• enfermedades relevantes: diabetes; obesity; metabolic disorders
• Información sobre el gen: human ... PRKAA2(5563) , PRKAB1(5563)

Descripción

Descripción general

Recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 and full length untagged AMPKγ1.

Aplicación

Research Category
Metabolism

Apoptosis & Cancer

Research Sub Category
Diabetes

Obesity

Metabolic Disorders

Acciones bioquímicas o fisiológicas

Protein Target: AMPK (α2, β1, γ1)

Target Sub-Family: CAMK

Envase

Also available in 10 μg size and in bulk

Also available in 250µg size as catalog # 14-902M - Call for pricing and availability.

Calidad

Routinely evaluated by phosphorylation of substrate peptide

Descripción de destino

AMPK (α2, β1, γ1)

Forma física

Cobalt-agarose

Almacenamiento y estabilidad

6 months at -70°C

Otras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H317
• Consejos de prudencia: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Clasificaciones de peligro: Skin Sens. 1
• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°C): Not applicable