14-865
p53-GST (recombinant protein)
Sinónimos:
transformation related protein 53
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About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.41
Productos recomendados
origen biológico
human
Nivel de calidad
Ensayo
~95% (SDS-PAGE)
Formulario
liquid
caducidad
1 yr
mol peso
Mw 72 kDa
fabricante / nombre comercial
Upstate®
concentración
0.5 mg/mL
técnicas
activity assay: suitable
solubilidad
water: soluble
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
Información sobre el gen
human ... TP53(120407068)
Descripción general
Research area: Apoptosis
N-terminal GST-tagged, recombinant full length human P53 protein, expressed in E. coli. Purified using glutathione agarose chromatography. Product Source: Full-length human p53 protein, expressed in e. coli. p53 protein is encoded by the tumor suppressor gene TP53 gene mapped on chromosome 17.
N-terminal GST-tagged, recombinant full length human P53 protein, expressed in E. coli. Purified using glutathione agarose chromatography. Product Source: Full-length human p53 protein, expressed in e. coli. p53 protein is encoded by the tumor suppressor gene TP53 gene mapped on chromosome 17.
Acciones bioquímicas o fisiológicas
In the cell, the p53 protein binds to DNA, leading to the activation of another gene that produces the p21 protein. This protein interacts with a cell division-stimulating protein (cdk2), preventing the cell from progressing to the next stage of cell division. Mutation in p53 protein leads to uncontrolled cell division resulting in tumor formation. The p53 protein is suggested to impede the phenotypic and genomic changes linked to cancer development through its intricate interaction with various signaling pathways including cell division, genomic stability maintenance, apoptosis, autophagy, immune response, and tumor microenvironment regulation.
Calidad
Routinely evaluated by SDS-PAGE and Coomassie Stain
Forma física
Glutathione agarose chromatography
Recombinant protein in buffer containing 20 mM Tris-HCl, pH 8.0, 100 mM KCl, 5mM glutathione, 0.5 mM EDTA, 0.5 mM DTT, 1 mM PMSF containing 20% glycerol.
Almacenamiento y estabilidad
1 year at -20°C
Otras notas
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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María Pedrero et al.
Biosensors, 6(4) (2016-11-24)
An amperometric magnetoimmunosensor for the determination of human p53 protein is described in this work using a sandwich configuration involving the covalent immobilization of a specific capture antibody onto activated carboxylic-modified magnetic beads (HOOC-MBs) and incubation of the modified MBs
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