1.20091

Sílice

EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Sinónimos: Dióxido de silicio
• Fórmula lineal: SiO₂
• Número de CAS: 7631-86-9
• Peso molecular: 60.08
• Número MDL: MFCD00011232
• Código UNSPSC: 12352201

Propiedades

• Agency: NF; Ph. Eur.
• Nivel de calidad: 500
• Línea del producto: EMPROVE^® ESSENTIAL
• formulario: fine powder
• tamaño de partícula: 17-25 μm (d50)
• bp: 2230 °C (lit.)
• mp: >1600 °C (lit.); 1710 °C
• aplicaciones: pharmaceutical; pharmaceutical; solid formulation; solubility enhancement
• temp. de almacenamiento: 2-30°C
• cadena SMILES: O=[Si]=O
• InChI: 1S/O2Si/c1-3-2
• Clave InChI: VYPSYNLAJGMNEJ-UHFFFAOYSA-N

Descripción

Descripción general

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Parteck^® SLC excipient is an innovative silica drug carrier that enhances drug solubility thanks to its unique surface structure, which can stabilize the amorphous state. This is especially relevant for poor glass forming APIs, which can be difficult to stabilize with other formulation technologies. Parteck^® SLC is also emerging as a first-in-class excipient to reduce the risk of unstable polymorphism and particle properties in drug development. In this application, Parteck^® SLC can homogenize both properties in a template-based formulation approach, with robust and reliable results.

Características y beneficios

• Solubility enhancement of APIs
• Unparalleled stabilization of the amorphous solid state
• Unique pore structure (6 nm diameter) and a very high surface area (500 m²/g)
• Perfect fit to stabilize poor glass former molecules
• Platform approach to manage API particle and polymorph variation
• No specific equipment/extra capital invest needed to stabilize the amorphous form of APIs
• High-end application support

Envase

1200910300 // Wide necked plastic bottle in corrugated box
1200911000 // Wide necked plastic bottle in corrugated box
1200919025 // Standard PE bag in PE square drum

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable