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Merck
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Key Documents

06-501

Sigma-Aldrich

Anti-STAT1 Antibody, CT

Upstate®, from rabbit

Sinónimos:

Anti-CANDF7, Anti-IMD31A, Anti-IMD31B, Anti-IMD31C, Anti-ISGF-3, Anti-STAT91

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

forma del anticuerpo

purified antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

reactividad de especies

mouse, human

fabricante / nombre comercial

Upstate®

técnicas

electrophoretic mobility shift assay: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotipo

IgG

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... STAT1(6772)

Descripción general

STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway.

STAT 1, is activated by a number of different ligands, including IFNalpha, IFNgamma, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions.

Especificidad

Recognizes STAT1.

Inmunógeno

GST fusion-protein containing the carboxy terminal 36 amino acids of human STAT1α

Aplicación

Detect STAT1 also known as Signal Transducer & Activator of Transcription 1 with Anti-STAT1 Antibody, CT (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA, IP & WB.

Calidad

routinely evaluated by immunoblot on RIPA lysates from human Jurkat cells, mouse CTLL or rat L6 cells

Descripción de destino

91 kDa

Forma física

Format: Purified

Nota de análisis

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation.
Rodriguez, JJ; Parisien, JP; Horvath, CM
Journal of virology null
Thrombopoietin signal transduction in purified murine megakaryocytes.
Drachman, J G, et al.
Blood, 89, 483-492 (1997)
Inhibition of interferon regulatory factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3
Sato, T., et al
Blood, 90, 4749-4758 (1997)
Ahmed A Mostafa et al.
PloS one, 9(1), e87377-e87377 (2014-01-30)
The coordinate regulation of HLA class II (HLA-II) is controlled by the class II transactivator, CIITA, and is crucial for the development of anti-tumor immunity. HLA-II in breast carcinoma is associated with increased IFN-γ levels, reduced expression of the estrogen
IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells.
Sriram, U; Xu, J; Chain, RW; Varghese, L; Chakhtoura, M; Bennett, HL; Zoltick, PW; Gallucci, S
Testing null

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