06-501

Anti-STAT1 Antibody, CT

Upstate^®, from rabbit

• Sinónimos: Anti-CANDF7, Anti-IMD31A, Anti-IMD31B, Anti-IMD31C, Anti-ISGF-3, Anti-STAT91
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• reactividad de especies: mouse, human
• fabricante / nombre comercial: Upstate^®
• técnicas: electrophoretic mobility shift assay: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• isotipo: IgG
• Nº de acceso NCBI: NM_007315
• Nº de acceso UniProt: P42224
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... STAT1(6772)

Descripción

Descripción general

STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway.

STAT 1, is activated by a number of different ligands, including IFNalpha, IFNgamma, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions.

Especificidad

Recognizes STAT1.

Inmunógeno

GST fusion-protein containing the carboxy terminal 36 amino acids of human STAT1α

Aplicación

Detect STAT1 also known as Signal Transducer & Activator of Transcription 1 with Anti-STAT1 Antibody, CT (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA, IP & WB.

Calidad

routinely evaluated by immunoblot on RIPA lysates from human Jurkat cells, mouse CTLL or rat L6 cells

Descripción de destino

91 kDa

Forma física

Format: Purified

Nota de análisis

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable