05-23-1200

Neurotensin

Potent hypothalamic peptide neurotransmitter.

• Sinónimos: Neurotensin, NT, NTS, Pyr-LYENKPRRPYIL
• Fórmula empírica (notación de Hill): C₇₈H₁₂₁N₂₁O₂₀
• Número de CAS: 39379-15-2
• Peso molecular: 1672.92
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white to off-white
• solubilidad: 5% acetic acid: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)
• Clave InChI: PCJGZPGTCUMMOT-UHFFFAOYSA-N

Descripción

Descripción general

Neurotensin (NT), a 13-amino acid peptide neurotransmitter encoded by the NTS gene. NT is located in the gastrointestinal tract and heterogeneously distributed in the mammalian central nervous system, and has many neurotransmitter-like characteristics. It influences various central and peripheral functions by interacting with three neurotensin receptors. It is linked to the modulation of dopaminergic systems and in the induction of changes in behavior, muscle relaxation, nociception, and hypothermia, as well as appetite, learning, memory, and fat metabolism. Moreover, it is a modulator of noradrenergic activity. It also acts as an endogenous anti-psychotic compound and lowers blood pressure, increases vascular permeability, and increases plasma levels of glucagon, glucose, growth hormone, and prolactin in rats. Additionally, it regulates the release of pituitary hormones from the brain and insulin, glucagon, and somatostatin from the gut.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Modulator of noradrenergic activity

Product does not compete with ATP.

Reversible: no

Envase

Yes

Advertencia

Toxicity: Standard Handling (A)

Secuencia

Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

Otras notas

Kinkead, B., et al. 1999. Biol. Psychiatr.46, 340.
Tyler, B.M., et al. 1998. Brain Res. 792, 246.
Tsuda, K., and Masuyuma, Y. 1993. Am. J. Hypertens. 6, 473.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable