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Merck
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Documentos clave

05-1100-M

Sigma-Aldrich

Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2

clone Sulfo-1C-A2, Upstate®, from mouse

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

Sulfo-1C-A2, monoclonal

reactividad de especies

human, mouse, bovine, porcine

reactividad de especies (predicha por homología)

all

fabricante / nombre comercial

Upstate®

técnicas

ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotipo

IgG2aκ

Descripción general

Sulfotyrosine is a common post-translational modification of secretory, plasma membrane, and lysosomal proteins. The sulfation reaction is catalyzed by specific sulfotransferase enzymes in the trans-Golgi-network. Tyrosine sulfation occurs in all multicellular organisms and up to 1% of the tyrosines in the total protein content of a cell can be sulfated. Sulfotyrosines mediates many receptor-ligand binding interactions, including the interaction of P-selectin glycoprotein ligand-1 with P-selectin, factor VIII binding to von Willebrand factor, and interactions between thrombin and hirudin. Sulfotyrosine is also involved in the entry of several parasites and viruses; for example, tyrosine sulfation of the HIV-1 co-receptor CCR5 is required for viral entry into host cells, and tyrosine sulfation of the Duffy antigen/receptor for chemokines is crucial for erythrocyte invasion by the malaria parasite Plasmodium vivax.

This clone was derived from the antibody described in Kehoe et al., 2006.

Especificidad

The antibody is predicted to recognize any sulfotyrosine, regardless of surrounding amino acid sequence.

Aplicación

Detect Sulfotyrosine with Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2 (Mouse Monoclonal Antibody), that has been shown to work in WB, IP, ELISA.

Calidad

Assayed using sulfatase treated bovine fibrinogen vs. untreated fibrinogen.

Descripción de destino

n/a

Forma física

Format: Purified

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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