934291

Thalidomide-O-amido-C₈-NH₂ trifluoroacetate

≥95.0%

• Sinónimos: N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate
• Fórmula empírica (notación de Hill): C₂₃H₃₀N₄O₆·C₂HF₃O₂
• Número de CAS: 1950635-16-1
• Peso molecular: 572.53
• Código UNSPSC: 12352200
• NACRES: NA.21

Propiedades

• ligand: thalidomide
• Nivel de calidad: 100
• Ensayo: ≥95.0%
• Formulario: powder or crystals
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]

Descripción

Aplicación

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Otras notas

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Información legal

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H312,H360D
• Consejos de prudencia: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Clasificaciones de peligro: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable