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764825

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG Mn 2,000, PLGA Mn 4,500

Sinónimos:

PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA

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About This Item

Fórmula lineal:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
Código UNSPSC:
12162002
NACRES:
NA.23

formulario

pellets

Nivel de calidad

100

cociente alimentación

lactide:glycolide 65:35

mol peso

PEG Mn 2,000
PLGA Mn 4,500
average Mn 6,500 (total)

marco temporal de la degradación

1-4 weeks

temperatura de transición

Tm 241-246 °C

PDI

≤2.0

temp. de almacenamiento

2-8°C

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Descripción general

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.

Aplicación

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
forming "stealth" pegylated microparticles

Características y beneficios

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCQ6851
MKCM0439
MKCK2243
MKCJ4906
MKCF5968

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Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., & Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

Artículos

Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers

One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Microfluidic-Assisted Manufacturing of Materials for Nanomedicine

Professor Nicola Tirelli (Istituto Italiano di Tecnologia, Italy) highlights the microfluidic-assisted method for fabricating well-defined and reproducible nanoparticles for drug delivery research.

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