Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

764779

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)

PEG average Mn 2,000, PDLLA average Mn 2,000

Sinónimos:

PEG-PDLLA

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Código UNSPSC:
12162002
NACRES:
NA.23

descripción

n=45, m=28 (typical)
typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)

Nivel de calidad

100

formulario

pellets

mol peso

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

marco temporal de la degradación

2-4 weeks

temperatura de transición

Tg 11 °C (PEG block)
Tm 244-248 °C
Tg 88 °C (PDLLA block)

PDI

≤1.4

temp. de almacenamiento

2-8°C

Descripción general

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as carriers for hydrophobic drugs like paclitaxel. PEG is the hydrophilic part and PDLLA is the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded.

Aplicación

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
water-solubilization of drugs

Características y beneficios

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
MKCM3361
MKCJ7857
MKCG4708
MKCD4773
MKCC9600

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing

Artículos

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Ver todo

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico