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Merck

475696

Sigma-Aldrich

Poly(ethylene glycol) diglycidyl ether

average MN 500, cross-linking reagent amine reactive, glycidyl

Sinónimos:

Polyethylene glycol, Diepoxy PEG, PEG diglycidyl ether, Polyoxyethylene bis(glycidyl ether)

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About This Item

Fórmula lineal:
C3H5O2-(C2H4O)n-C3H5O
Número de CAS:
Número MDL:
Código UNSPSC:
12162002
NACRES:
NA.23

Nombre del producto

Poly(ethylene glycol) diglycidyl ether, average Mn 500

mol peso

average Mn 500

idoneidad de la reacción

reagent type: cross-linking reagent
reactivity: amine reactive

índice de refracción

n20/D 1.47

Ω-final

epoxy

α-final

epoxy

arquitectura del polímero

shape: linear
functionality: homobifunctional

temp. de almacenamiento

2-8°C

cadena SMILES

O1C(C1)COCCOCC2OC2

InChI

1S/C8H14O4/c1(9-3-7-5-11-7)2-10-4-8-6-12-8/h7-8H,1-6H2

Clave InChI

AOBIOSPNXBMOAT-UHFFFAOYSA-N

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Descripción general

Poly(ethylene glycol) diglycidyl ether (PEGDGE) shows highly solubility in water. Hence, it easily undergoes hydrolysis followed by ring cleavage reaction in aqueous solution, yielding hydroxyl group. PEGDGE combines with proteins covalently or non-covalently. PEGDGE is widely used in chemical industries for cross linking and surface modifier.

Aplicación

The high solubility of PEGDGE has been successfully employed to immobilize glucose oxidase, d-amino acid oxidase and glutamate oxidase. It may be used as a component for the development of microelectrode biosensors to detect hydrogen peroxide and nitric oxide.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

386.6 °F - closed cup

Punto de inflamabilidad (°C)

197.00 °C - closed cup

Equipo de protección personal

Eyeshields, Gloves


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Artículos

Patterning of PEG-based Hydrogels - Engineering Spatial Complexity

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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