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Fumonisin B1

reference material, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Synonym(s):

Fumonisin B1 from Fusarium moniliforme, Macrofusine

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About This Item

Empirical Formula (Hill Notation):
C34H59NO15
CAS Number:
Molecular Weight:
721.83
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard
reference material

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

−20°C

SMILES string

CCCC[C@@H](C)[C@@H](OC(=O)C[C@@H](CC(O)=O)C(O)=O)[C@H](C[C@@H](C)C[C@H](O)CCCC[C@@H](O)C[C@H](O)[C@H](C)N)OC(=O)C[C@@H](CC(O)=O)C(O)=O

InChI

1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)/t19-,20+,21-,22+,23+,24+,25+,26-,27-,32+/m0/s1

InChI key

UVBUBMSSQKOIBE-DSLOAKGESA-N

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General description

Fumonisins are a family of mycotoxins that are characterized by their structurally related homologs. They are generally produced by fungi of Fusarium species.

Application

Fumonisin B1 may be used as an analytical reference standard for the determination of the analyte in:
  • Swine liver by high performance liquid chromatography-fluorescence detection (HPLC-FLD).
  • Cereals by HPLC.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Fungal metabolite believed to cause leukoencephalomalacia in horses.

Analysis Note

purity : ≥92.5% (HPLC)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Repr. 2 - STOT RE 2

Target Organs

Kidney,Liver

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Simple method for the simultaneous isolation and determination of fumonisin B1 and its metabolite aminopentol-1 in swine liver by liquid chromatography-fluorescence detection.
Pagliuca G, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 819(1), 97-103 (2005)
Influence of experimental parameters on the fluorescence response and recovery of the high-performance liquid chromatography analysis of fumonisin B1.
Samapundo S, et al.
Journal of Chromatography A, 1109(2), 312-316 (2006)
J M Soriano et al.
Progress in lipid research, 44(6), 345-356 (2005-11-04)
Fumonisins are a group of mycotoxins produced primarily by Fusarium moniliforme. Several fumonisins have been isolated through out the years but only fumonisin B1, B2 and B3 are the ones present in naturally contaminated foods, with B1 being the most
Anil A Chuturgoon et al.
Toxicology letters, 227(1), 50-55 (2014-03-13)
Fumonisin B₁ (FB₁), a common mycotoxin contaminant of maize, is known to inhibit sphingolipid biosynthesis and has been implicated in hepatocellular carcinoma promoting activity in humans and animals. MicroRNAs (miRNA) are small noncoding RNAs that regulate gene expression via translational
Ronald T Riley et al.
Molecular nutrition & food research, 56(9), 1445-1455 (2012-07-21)
Fumonisins (FB) are mycotoxins found in maize. The purpose of this study was to (i) determine the relationship between FB(1) , FB(2) , and FB(3) intake and urinary excretion in humans, (ii) validate a method to isolate urinary FB on

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Mycotoxin chemistry is diverse with some toxins being relatively harmless and some very dangerous like aflatoxins, citrinin, ergot alkaloids fumonisins. For all Food & Beverage manufacturers and testers, find a detailed list of products for each step of your mycotoxin analysis workflow.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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