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C-144

Supelco

Cannabidiolic acid solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C22H30O4
CAS Number:
1244-58-2
Molecular Weight:
358.47
EC Number:
200-835-2
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

cannabis testing
cannabis testing

format

single component solution

shipped in

dry ice

storage temp.

−70°C

InChI

1S/C22H30O4/c1-5-6-7-8-15-12-18(23)20(21(24)19(15)22(25)26)17-11-14(4)9-10-16(17)13(2)3/h11-12,16-17,23-24H,2,5-10H2,1,3-4H3,(H,25,26)/t16-,17+/m0/s1

InChI key

WVOLTBSCXRRQFR-DLBZAZTESA-N

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General description

This Certified Spiking Solution® is suitable for cannabidiolic acid testing methods by GC/MS, LC/MS or HPLC for applications in the testing of Cannabis potency or impurity profiling, pharmaceutical research, and forensic analysis. Cerilliant solution Certified Reference Materials (CRMs) of cannabinoids are supplied in a convenient, quantitative, US DEA-exempt solution format and with TK#s for Canadian customers.

Cannabidiolic acid (CBDA) is one of the main cannabinoids found in plants of the Cannabaceae family, such as hemp and cannabis. It occurs mostly in the leaves of the plant and on decarboxylation in the presence of light or heat forms cannabidiol (CBD). It is known to show anxiolytic, anti-inflammatory, anti-hyperalgesic, antiemetic, neuroprotective, and anticonvulsant activities.

Application

The Certified Reference Material (CRM) in solution can also be used as follows:
  • Determination of four cannabinoids from an oil matrix using reversed-phase high-performance liquid chromatography (RP-HPLC) combined with a diode array detector (DAD)
  • Analysis of hemp seed oil samples for identification and estimation of seven major cannabinoids by HPLC coupled to a UV detector
  • Separation and determination of CBD and CBDA from hemp oil samples using liquid-liquid extraction and HPLC-DAD
  • Multi-analysis of 11 cannabinoids in biomass and extracts of different cannabis varieties by an HPLC-UV method, following the International Conference on Harmonization (ICH) Tripartite Guideline for Validation of Analytical Procedures
  • Development and validation of an HPLC-DAD method for the simultaneous analysis of five major neutral and acidic cannabinoids in cannabis and hashish samples
  • Gas chromatography-mass spectrometry (GC-MS) analysis of ten main cannabinoids from hemp inflorescences following their silylation and esterification for derivatization

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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HPLC-DAD analysis of hemp oil supplements for determination of four cannabinoids: Cannabidiol, cannabidiolic acid, cannabinol and delta 9-Tetrahydrocannabinol
Madej K, et al.
Separations, 8, 227-227 (2021)
Alice Palermiti et al.
Pharmaceuticals (Basel, Switzerland), 14(5) (2021-06-03)
Medical cannabis is increasingly being used in the treatment and support of several diseases and syndromes. The quantitative determination of active ingredients (delta-9 tetrahydrocannabinol, THC, and cannabidiol, CBD) in galenic oily preparations is prescribed by law for each produced batch.
Federica Pigliasco et al.
Molecules (Basel, Switzerland), 25(16) (2020-08-14)
The aim of this work is to evaluate volumetric absorptive microsampling (VAMS) from capillary blood as an alternative strategy for therapeutic drug monitoring (TDM) in patients treated with the newly available GW-purified form of cannabidiol (Epidiolex®). A fast ultra-high-performance liquid

Articles

UHPLC Analysis of Cannabinoids on Ascentis Express C18

As the popularity of cannabis-infused products increases, there is a growing need to characterize the type and content of the cannabinoids found in the product. This application demonstrates the ability of the Ascentis Express C18 column to baseline resolve 14 structurally-similar cannabinoids, in under seven minutes, with excellent peak shape.

Cannabis Testing

The cannabinoids found in the Cannabis plant commonly referred to as marijuana, have grown in popularity for treating a variety of ailments from arthritis, glaucoma, and chronic pain to malnutrition, multiple sclerosis, and cancer.

HPLC Analysis of Active Cannabinoid Compounds in Gummy Bear Candy on Ascentis® Express Biphenyl with UV Detection after Extraction

Tetrahydrocannabinolic acid A solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material.

Protocols

Analysis of Active Cannabis Compounds in Edible Food Products: Gummy Bears and Brownies

Potency testing in marijuana-infused edibles is an important problem that analytical labs are facing due to the complexity of the involved matrices. Concentration of active ingredients in these edibles can range from a few parts per million to 3.5 parts per thousand. This application demonstrates the extraction and HPLC-UV analysis of the active compounds.

UHPLC Analysis Cannabinoids Ascentis Express

As the popularity of cannabis-infused products increases, there is a growing need to characterize the type and content of the cannabinoids found in the product. This application demonstrates the ability of the Ascentis Express C18 column to baseline resolve 14 structurally-similar cannabinoids, in under seven minutes, with excellent peak shape.

UHPLC (Isocratic) Analysis of 14 Cannabinoids on Ascentis® Express C18

Tetrahydrocannabinolic acid A solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material; Cannabichromenic Acid (CBCA) solution, 1.0 mg/mL in acetonitrile, certified reference material, ampule of 1 mL

Analysis of Active Cannabis Compounds (Cannabinoids) in Edible Food Products: Gummy Bears and Brownies

Rapid potency testing of marijuana-infused edibles using LC/MS on a biphenyl stationary phase detected eleven cannabinoids.

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