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900406P

Avanti

pacFA GalCer

Avanti Polar Lipids 900406P, powder

Synonym(s):

D-galactosyl-β-1,1′ N-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C39H69N3O8
CAS Number:
2456348-71-1
Molecular Weight:
707.98
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (900406P-1mg)
pkg of 1 × 5 mg (900406P-5mg)

manufacturer/tradename

Avanti Polar Lipids 900406P

lipid type

click reagents

shipped in

dry ice

storage temp.

−20°C

SMILES string

C#CCCCC1(N=N1)CCCCCCCCC(N[C@](CO[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)([H])[C@H](O)/C=C/CCCCCCCCCCCCC)=O

General description

The pacFA lipid contains a photoactivable diazirine ring with a clickable alkyne group.

Biochem/physiol Actions

D-galactosyl-β-1,1′ N-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-D-erythro-sphingosine (pacFA GalCer) may be used for a global analysis of protein-lipid interactions in living cells. pacFA acts as a precursor for the biosynthesis of bifunctional lipids. Proteins in contact with the bifunctional lipids are then cross-linked by ultraviolet (UV) irradiation of the diazirine ring. Finally, click chemistry is used to label the alkyne with a reporter molecule.

Packaging

5 mL Amber Glass Screw Cap Vial (900406P-1mg)
5 mL Amber Glass Screw Cap Vial (900406P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.
Per Haberkant et al.
Angewandte Chemie (International ed. in English), 52(14), 4033-4038 (2013-03-02)
Per Haberkant et al.
Biochimica et biophysica acta, 1841(8), 1022-1030 (2014-01-21)
Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as

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