930512

VH 032 amide-PEG₃-acid

≥95.0%

• Synonym(s): (S, R, S)-AHPC-PEG₃-acid, 3-Dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)ethoxy]ethoxy}propanoic acid, 3-{2 -[2-(2-{[(2S)-1-[(2S,4R)-4-Hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3, N-[3-[2-[2-(2-Carboxyethoxy)ethoxy]ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, L-Prolinamide
• Empirical Formula (Hill Notation): C₃₂H₄₆N₄O₉S
• CAS Number: 2140807-42-5
• Molecular Weight: 662.79
• MDL number: MFCD32693314
• UNSPSC Code: 12352106

Properties

• ligand: VH032
• Quality Level: 100
• Assay: ≥95.0%
• form: powder
• functional group: carboxylic acid
• storage temp.: 2-8°C
• SMILES string: OC(CCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O

Description

Application

VH 032 amide-PEG₃-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation


Protein Degrader Building Blocks

Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable