BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.

BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.

Antimicrobial agents and chemotherapy (2007-09-26)

Parmjeet Randhawa, Noush Afarin Farasati, Yuchen Huang

ZUSAMMENFASSUNG

BK virus is an important pathogen in kidney transplant recipients. In vitro studies demonstrated slight antiviral activity for chloroquine and nystatin. A sialic acid derivative, BTB11968, was identified as a lead compound for further development.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

C9754

Sigma-Aldrich

Colchicin, ≥95% (HPLC), powder

C3915

Sigma-Aldrich

Colchicin, BioReagent, suitable for plant cell culture, ≥95% (HPLC)

M6882

Sigma-Aldrich

Methyl α-D-Mannopyranosid, ≥99.0% (HPLC)

O3757

Sigma-Aldrich

Octyl β-D-glucopyranoside solution, ≥95% (HPLC), 50 % (w/v) in H₂O

O8001

Sigma-Aldrich

Octyl-β-D-Glucopyranosid, ≥98% (GC)

N7507

Sigma-Aldrich

Nonyl-β-D-glucopyranosid, ≥97.0% (GC)

18842

Sigma-Aldrich

Octyl-β-D-glucopyranosid 100 mM -Lösung

67770

Millipore

Methyl α-D-Mannopyranosid, ≥99.0%, suitable for microbiology, enables differentiation between species of Listeria

O9882

Sigma-Aldrich

Octyl-β-D-Glucopyranosid, BioXtra, ≥98% (GC)