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1461003

USP

Niacin

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

Nicotinsäure, 3-Picolinsäure, Niacin, Pellagra Präventivfaktor, Pyridin-3-carbonsäure, Vitamin B3

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About This Item

Empirische Formel (Hill-System):
C6H5NO2
CAS-Nummer:
59-67-6
Molekulargewicht:
123.11
Beilstein:
109591
MDL-Nummer:
MFCD00006391
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329750552
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

nicotinic acid

Hersteller/Markenname

USP

Methode(n)

HPLC: suitable

mp (Schmelzpunkt)

236-239 °C (lit.)

Löslichkeit

ethanol: 12.5 g/L at 25 °C
water: soluble 180 g/L at 20 °C

Dichte

1.473 g/cm3 at 25 °C

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

SMILES String

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChIKey

PVNIIMVLHYAWGP-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Niacin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Niacin Tablets
  • Niacin Injection
  • Niacin Extended-Release Tablets
  • Inositol Niacinate
  • Niacinamide
  • Water-Soluble Vitamins Capsules

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

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Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319

Gefahreneinstufungen

Eye Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

379.4 °F - closed cup

Flammpunkt (°C)

193 °C - closed cup

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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1291559

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Nicotinic Acid A component of coenzymes NAD+ and NADP+.

Millipore

481918

Nicotinic Acid

Riboflavin United States Pharmacopeia (USP) Reference Standard

USP

1603006

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Nicotinsäure für die Qualifizierung von Anlagen European Pharmacopoeia (EP) Reference Standard

Y0001995

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Sigma-Aldrich

8.18714

Nicotinic acid

Vaijinath S Kamanna et al.
Current opinion in lipidology, 24(3), 239-245 (2013-04-27)
This review focuses on the current understanding of the physiological mechanisms of action of niacin on lipid metabolism and atherosclerosis. Emerging findings indicate that niacin decreases hepatic triglyceride synthesis and subsequent VLDL/LDL secretion by directly and noncompetitively inhibiting hepatocyte diacylglycerol
James B Kirkland
Mutation research, 733(1-2), 14-20 (2011-12-06)
Through its involvement in over 400 NAD(P)-dependent reactions, niacin status has the potential to influence every area of metabolism. Niacin deficiency has been linked to genomic instability largely through impaired function of the poly ADP-ribose polymerase (PARP) family of enzymes.
Matilda Florentin et al.
Current vascular pharmacology, 9(4), 385-400 (2011-02-15)
Treatment with statins has significantly reduced cardiovascular morbidity and mortality, an effect attributed to both the low-density lipoprotein cholesterol (LDL-C) lowering capacity and the pleiotropic actions of these drugs. However, residual risk remains even after intense LDL-C lowering. Therefore, additional
Janet E Digby et al.
Current opinion in lipidology, 20(4), 321-326 (2009-06-06)
Nicotinic acid is the most potent treatment clinically available for lowering LDL cholesterol and VLDL cholesterol and raising HDL cholesterol. The strong inverse relationship between coronary heart disease risk and HDL cholesterol at all levels of LDL cholesterol has, therefore
E T Bodor et al.
British journal of pharmacology, 153 Suppl 1, S68-S75 (2007-11-27)
Nicotinic acid has been used for decades to treat dyslipidaemic states. In particular its ability to raise the plasma HDL cholesterol concentration has led to an increased interest in its pharmacological potential. The clinical use of nicotinic acid is somewhat
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