PHL89593

Camptothecin

phyproof^® Reference Substance

• Synonym(e): (S)-(+)-Camptothecin
• Empirische Formel (Hill-System): C₂₀H₁₆N₂O₄
• CAS-Nummer: 7689-03-4
• Molekulargewicht: 348.35
• Beilstein: 631069
• MDL-Nummer: MFCD00081076
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: primary reference standard
• Produktlinie: phyproof^® Reference Substance
• Assay: ≥90.0% (HPLC)
• Form: powder
• Hersteller/Markenname: PhytoLab
• mp (Schmelzpunkt): 260 °C (dec.) (lit.)
• Lagertemp.: 2-8°C
• SMILES String: CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
• InChI: 1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
• InChIKey: VSJKWCGYPAHWDS-FQEVSTJZSA-N

Beschreibung

Allgemeine Beschreibung

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Anwendung

• Co-delivery system for camptothecin and doxorubicin: Research on dendritic polymer prodrug-based unimolecular micelles demonstrated a pH-responsive co-delivery mechanism for camptothecin and doxorubicin, offering a synergistic effect in controlled drug release (Chen and Liu, 2024).



• Investigation into camptothecin′s role in chronic myeloid leukemia: The study explored the therapeutic potential of FL118, a camptothecin derivative, against chronic myeloid leukemia resistant to BCR-ABL inhibitors, targeting RNA helicase DDX5 (Takeda et al., 2024).

Rechtliche Hinweise

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H340
• P-Sätze: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Gefahreneinstufungen: Acute Tox. 3 Oral - Muta. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable