13024AST

Astec^® CHIROBIOTIC^® R Chiral (5 μm) HPLC Columns

L × I.D. 25 cm × 4.6 mm, HPLC Column

• Synonym(e): Chiral Recognition HPLC Column
• UNSPSC-Code: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Eigenschaften

• product name: Astec^® Chirobiotic^® R Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
• Materialien: stainless steel column
• Qualitätsniveau: 100
• Beschreibung: HPLC column
• Produktlinie: Astec^®
• Verpackung: pkg of 1 ea
• Hersteller/Markenname: Astec^®
• Parameter: 0-45 °C temperature; 241 bar pressure (3500 psi)
• Methode(n): HPLC: suitable; LC/MS: suitable
• L × ID: 25 cm × 4.6 mm
• Matrix: high-purity silica gel particle platform; fully porous particle
• Aktive Matrixgruppe: ristocetin A glycopeptide phase
• Partikelgröße: 5 μm
• Porengröße: 100 Å
• operating pH range: 3.5-6.8
• Trenntechnik: chiral

Beschreibung

Allgemeine Beschreibung

CHIROBIOTIC^® R, based on the ristocetin A glycopeptide covalently bonded to high purity silica particles, has shown particular applicability to enantiomers of anionic compounds. Selectivity on CHIROBIOTIC^® R strongly correlates to the organic modifier, favoring the alcohol-type mobile phases by a large margin.

• Bonded phase: Ristocetin A
• Operating pH range: 3.5 - 6.8
• Particle diameter: 5, 10 or 16 μm
• Pore size: 100 Å

CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature

Anwendung

• Sensitive Determination of Lactic Acid Isomers: The Astec^® CHIROBIOTIC^® R Chiral HPLC Column was crucial in a study by Henry H et al., where it facilitated the sensitive determination of D-lactic acid and L-lactic acid in urine using high-performance liquid chromatography-tandem mass spectrometry. This method is pivotal for clinical diagnostic applications, showcasing the column′s ability to resolve similar compounds that are challenging to differentiate by other means (Henry H et al., 2012).



• Enantioseparation of Cyclopentanecarboxylic and Cyclohexanecarboxylic Acids: The column was also utilized by Berkecz R et al. to achieve high-performance liquid chromatographic enantioseparation of complex 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids. This application underscores the column′s versatility and efficacy in separating closely related chiral acids, essential for biochemical research and pharmaceutical product development (Berkecz R et al., 2009).

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Rechtliche Hinweise

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC