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Merck

V2264

Sigma-Aldrich

Vinorelbine ditartrate salt hydrate

≥98% (HPLC), powder

Synonym(e):

3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate

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About This Item

Empirische Formel (Hill-System):
C45H54N4O8 · 2C4H6O6 · xH2O
CAS-Nummer:
Molekulargewicht:
1079.11 (anhydrous basis)
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Qualitätsniveau

Assay

≥98% (HPLC)

Form

powder

Farbe

off-white

Löslichkeit

H2O: 10 mg/mL

Ersteller

Pierre Fabre

Versandbedingung

wet ice

Lagertemp.

2-8°C

SMILES String

[H]O[H].O[C@H]([C@@H](O)C(O)=O)C(O)=O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@]12C[N@H](CC(CC)=C1)Cc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC

InChI

1S/C45H54N4O8.2C4H6O6.H2O/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10;/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10);1H2/t28-,37-,38+,39+,42+,43+,44-,45-;2*1-,2-;/m011./s1

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manufacturer/tradename

Bel-Art F18746-0001

manufacturer/tradename

Bel-Art F18746-0000

manufacturer/tradename

Bel-Art F18746-0002

manufacturer/tradename

Bel-Art F18746-0003

packaging

pack of 1 ea

packaging

pack of 1 ea

packaging

pack of 1 ea

packaging

pack of 1 ea

size

9.7 in. × 4.1 in. × 2 1/2 in.

size

9.7 in. × 4.1 in. × 2 1/2 in.

size

9.7 in. × 4.1 in. × 2 1/2 in.

size

9.7 in. × 4.1 in. × 2 1/2 in.

Biochem./physiol. Wirkung

Vinorelbine is a potent anti-mitotic, anti-tumor agent. Vinorelbine inhibits microtubule assembly. Low neurotoxicity is related to its higher affinity for mitotic microtubules than for axonal microtubules.

Leistungsmerkmale und Vorteile

This compound was developed by Pierre Fabre. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Juliana Teixeira Fiquer et al.
Journal of affective disorders, 238, 636-644 (2018-06-30)
It is unclear if individuals with Major Depressive Disorder (MDD) present different nonverbal behavior (NVB) compared with healthy individuals, and also if depression treatments affect NVB. In this study, we compared the NVB of MDD subjects and healthy controls. We
Fabio Castiglione et al.
Current urology reports, 18(11), 90-90 (2017-10-02)
Due to the increasing numbers of radical prostatectomies (RP) performed for prostate cancer, a substantial number of patients are now suffering from post-operative erectile dysfunction (ED). The aim of this study is to summarize the current literature on surgical techniques
Hongyang Li et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 89, 1277-1285 (2017-03-23)
Vinorelbine (NVB) is a semi-synthetic vinca alkaloid that is approved for the clinical therapy of lung cancer. However, the clinical application of NVB was limited because of the acquisition of resistance and inacceptable toxicity. Therefore, it is of great interest
Lihui Wang et al.
Cell death & disease, 8(4), e2746-e2746 (2017-04-14)
Chemotherapeutic agents are generally used as a frontline therapy for non-small cell lung cancer (NSCLC). However, resistance to chemotherapy arises rapidly in NSCLC, and the reasons for chemotherapy resistance have not been fully determined. Here, we found cisplatin, but not
Man Su Kim et al.
Journal of microbiology (Seoul, Korea), 57(5), 405-412 (2019-02-24)
Xanthorrhizol (XTZ), isolated from Curcuma xanthorrhiza, has potent antifungal and antibacterial activity. It shows very strong activity against Gram-positive bacteria, such as Streptococcus mutans and Staphylococcus aureus, but is generally not active against Gram-negative bacteria. In this study, we explored

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