SRP4651

PTHrP human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• Synonym(e): PLP
• MDL-Nummer: MFCD01635684
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: ≥98% (HPLC); ≥98% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~9.8 kDa
• Verpackung: pkg of 50 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Verunreinigungen: endotoxin, tested
• NCBI-Hinterlegungsnummer: P12272
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... PTHLH(5744)

Beschreibung

Allgemeine Beschreibung

Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. It is also responsible for most cases of humoral hypercalcemia of malignancy. Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.

Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.

Anwendung

The human parathyroid hormone-like related protein (PTHrP) has been used as an osteoarthritis-associated factor regulating hypertrophic differentiation of human chondrocytes. It has also been used in the regulation of the expression of Smpd3 (Sphingomyelin phosphodiesterase 3) in chondrocytes.

Biochem./physiol. Wirkung

The gene PTHrP (parathyroid hormone-like related protein) encodes a protein involved in skeletal development. It binds to the receptor activated by PTH (parathyroid hormone) and functions in smooth muscle relaxation, regulation of cellular proliferation and differentiation. It also regulates endochondral bone development and proliferation of growth plate chondrocytes. It regulates fetal blood calcium and placental calcium transport. It has been associated with malignant hypercalcemia. Mutation in this gene has been associated with brachydactyly type E2 (BDE2).

Physikalische Form

Sterile filtered and lyophilized without additives.

Rekonstituierung

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3