SML3941

DUB-IN-1

≥98% (HPLC)

• Synonym(e): 9-Benzyloxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-Phenylmethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, DUB Inhibitor 1, DUBs Inhibitor 1, DUBs-IN-1, Deubiquitinase Inhibitor 1
• Empirische Formel (Hill-System): C₂₀H₁₁N₅O
• CAS-Nummer: 924296-18-4
• Molekulargewicht: 337.33
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: -10 to -25°C

Beschreibung

Biochem./physiol. Wirkung

Potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor.

DUB-IN-1 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 850 nM/USP8, >100 µM/USP7). DUB-IN-1 inhibits the proliferation (200-800 nM for 24 or 48h; LN229, U87MG, and T98G cells), invasion (500-800 nM for 48 or 96h; LN229 and T98G cells), and stemness (500-800 nM for 7 or 14 days; LN229 and T98G cells) in GBM cultures.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable