SML3658

BMS-470539 dihydrochloride

≥98% (HPLC)

• Synonym(e): (S)-2-Amino-N-((R)-1-(4-butyryl-4-phenylpiperidin-1-yl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl)-3-(1-methyl-1H-imidazol-5-yl)propanamide dihydrochloride, 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-Butanone dihydrochloride, BMS 470539 dihydrochloride, BMS470539 dihydrochloride
• Empirische Formel (Hill-System): C₃₂H₄₁N₅O₄·2HCl
• CAS-Nummer: 2341796-82-3
• Molekulargewicht: 632.62
• UNSPSC-Code: 41115709
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 2 mg/mL, clear (Warmed)
• Lagertemp.: -10 to -25°C
• SMILES String: CCCC(C1(C2=CC=CC=C2)CCN(CC1)C([C@H](NC([C@@H](N)CC3=CN=CN3C)=O)CC4=CC=C(C=C4)OC)=O)=O.[2HCl]

Beschreibung

Biochem./physiol. Wirkung

BMS-470539 is a highly potent and selective melanocortin-1 receptor (MC-1R; MC1R) agonist (AMP stimulation EC50 = 11.6/16.2/16.8 nM using B16/HBL/CHO-MC1R; little or no potency toward MC2R, MC3R MC4R MC5R) with anti-inflammatory efficacy in mice in vivo (15-100 μmol/kg via i.v. or s.c. 0.5-1 h prior to 1 μg LPS s.c.).

Vorsicht

Hygroscopic

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable