SML3424

DIM-C-pPhOH

≥98% (HPLC)

• Synonym(e): 1,1-Bis(3′-indolyl)-1-(p-hydroxyphenyl)methane, 4-(Di-1H-indol-3-ylmethyl)phenol; (4-Hydroxyphenyl)bis(1H-indol-3-yl)methane, 7,7-Bis(3-indolyl)-p-cresol, C-DIM 8, CDIM8
• Empirische Formel (Hill-System): C₂₃H₁₈N₂O
• CAS-Nummer: 151358-47-3
• Molekulargewicht: 338.40
• MDL-Nummer: MFCD03723253
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: off-white to pink
• Löslichkeit: DMSO: 2 mg/mL
• Lagertemp.: −20°C
• SMILES String: OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

Beschreibung

Biochem./physiol. Wirkung

DIM-C-pPhOH is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhOH decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231breast cancer cells. DIM-C-pPhOH inhibits migration of Rh30 and MDA-MB-231 cancer cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable