SML3218

Odevixibat

≥98% (HPLC)

• Synonym(e): (2S)-2-[(2R)-2-(2-{[3,3-Dibutyl-7-(methylsulfanyl)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1λ6,2,5-benzothiadiazepin-8-yl]oxy}acetamido)-2-(4-hydroxyphenyl)acetamido]butanoic acid, (2S)-2-[[(2R)-2-[[2-[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]butanoic acid, A 4250, A-4250, A4250, AZD 8294, AZD-8294, AZD8294
• Empirische Formel (Hill-System): C₃₇H₄₈N₄O₈S₂
• CAS-Nummer: 501692-44-0
• Molekulargewicht: 740.93
• MDL-Nummer: MFCD32710220
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: O=S1(C2=CC(OCC(N[C@H](C3=CC=C(C=C3)O)C(N[C@@H](CC)C(O)=O)=O)=O)=C(SC)C=C2N(C4=CC=CC=C4)CC(CCCC)(N1)CCCC)=O

Beschreibung

Biochem./physiol. Wirkung

Odevixibat is an orally active, potent and selective ileal bile acid transporter (IBAT; ASBT; SLC10A2) inhibitor that improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis (0.01% w/w in diet).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable