SML2918

INT131

≥98% (HPLC)

• Synonym(e): 2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide, AMG-131, T0903131
• Empirische Formel (Hill-System): C₂₁H₁₂Cl₄N₂O₃S
• CAS-Nummer: 315224-26-1
• Molekulargewicht: 514.21
• MDL-Nummer: MFCD13152369
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: [S](=O)(=O)(Nc2cc(c(c(c2)Cl)Oc3cnc4c(c3)cccc4)Cl)c1c(cc(cc1)Cl)Cl
• InChI: 1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
• InChIKey: NMRWDFUZLLQSBN-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

INT131 is a brain penetrant, non-thiazolidinedione, highly potent and selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator (SPPARM) that displays anti-diabetic activities. INT131 is a partial, rather than a full agonist of PPARγ, and in clinical trials has shown increased glucose tolerance without the weight gain and cardiovascular side effects seen with some of the full agonist.

Selective PPAR Modulator (SPPARM)

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids