SML2392

DREADD Agonist 21 dihydrochloride

≥98% (HPLC), powder, DREADD agonist

• Synonym(e): 11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₈N₄ · 2HCl
• CAS-Nummer: 56296-18-5
• Molekulargewicht: 351.27
• MDL-Nummer: MFCD25121806
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• product name: DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: yellow to brown
• Löslichkeit: H₂O: 2 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1

Beschreibung

Biochem./physiol. Wirkung

Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable