SML1971

LLY-284

≥98% (HPLC)

• Synonym(e): (2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol, (S)-5′-phenyl-7-deazaadenosine; 6-amino-9-[(S)-5′-phenyl(ribofuranosyl)]-7-deazapurine, LLY 284, LLY284
• Empirische Formel (Hill-System): C₁₇H₁₈N₄O₄
• CAS-Nummer: 2226515-75-7
• Molekulargewicht: 342.35
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Lagertemp.: 2-8°C
• SMILES String: O[C@@H]1[C@@H]([C@@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O
• InChIKey: WWOOWAHTEXIWBO-CNUKPYSBSA-N

Beschreibung

Biochem./physiol. Wirkung

LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283 (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probe, LLY-283, please visit the LLY-283 probe summary on the Structural Genomics Consortium (SGC) website.

LLY-283, the active probe, is available from Sigma. To learn more about and purchase LLY-283, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Less potent diastereomer and control compound for the potent and selective SAM-competitive PRMT5 inhibitor LLY-283.

Leistungsmerkmale und Vorteile

LLY-284 is a negative control for LLY-283, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable