SML1605

OTX015

≥98% (HPLC)

• Synonym(e): 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)-, OTX-015
• Empirische Formel (Hill-System): C₂₅H₂₂ClN₅O₂S
• CAS-Nummer: 202590-98-5
• Molekulargewicht: 491.99
• MDL-Nummer: MFCD26960949
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825491
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to light brown
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C(NC(C=C1)=CC=C1O)C[C@H]2C3=NN=C(C)N3C(SC(C)=C4C)=C4C(C5=CC=C(Cl)C=C5)=N2
• InChI: 1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
• InChIKey: GNMUEVRJHCWKTO-FQEVSTJZSA-N
• Angaben zum Gen: human ... BRD2(6046) , BRD3(8019) , BRD4(23476) , BRDT(676)

Beschreibung

Biochem./physiol. Wirkung

It binds to bromodomain and extra-terminal domain (BET) proteins and inhibits their binding to the chromatin. This in turn prevents gene transcription. OTX015 has been shown to inhibit proliferation of cells in haematological malignancies.

OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4).

OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable