SML1504

Tegaserod maleate

≥98% (HPLC)

• Synonym(e): 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate
• Empirische Formel (Hill-System): C₁₆H₂₃N₅O · C₄H₄O₄
• CAS-Nummer: 189188-57-6
• Molekulargewicht: 417.46
• MDL-Nummer: MFCD09028009
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825925
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: N=C(NCCCCC)N/N=C/C1=CNC2=C1C=C(OC)C=C2.OC(/C=C\C(O)=O)=O
• InChI: 1S/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1-
• InChIKey: CPDDZSSEAVLMRY-FEQFWAPWSA-N
• Angaben zum Gen: human ... HTR4(3360)

Beschreibung

Anwendung

Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.

Biochem./physiol. Wirkung

It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.

Tegaserod is a potent full agonist at serotonin 5-HT4 receptors with an EC₅₀ of 7 nM.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable