SML1210

Almotriptanmalat

≥98% (HPLC)

• Synonym(e): 3-[2-(Dimethylamino)-ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-malat
• Empirische Formel (Hill-System): C₁₇H₂₅N₃O₂S · C₄H₆O₅
• CAS-Nummer: 181183-52-8
• Molekulargewicht: 469.55
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 10 mg/mL, clear
• Lagertemp.: −20°C
• InChI: 1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
• InChIKey: QHATUKWEVNMHRY-UHFFFAOYSA-N

Beschreibung

Anwendung

Almotriptan at an oral dose of 12.5 mg, is recommended to be safe for treating migraine.

Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.

Biochem./physiol. Wirkung

Almotriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Almotriptan has low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower. Affinity for 5-HT(7) and 5-HT(1A) receptors was approximately 40 and 60 times lower than that for 5-HT(1B/1D) receptors, respectively.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable