D101

(±)-DOI hydrochloride

≥98% (HPLC), solid,  5-HT2 serotonin receptor agonist

• Synonym(e): (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride, (±)-DOI
• Empirische Formel (Hill-System): C₁₁H₁₆INO₂ · HCl
• CAS-Nummer: 42203-78-1
• Molekulargewicht: 357.62
• MDL-Nummer: MFCD00055199
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278092
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: (±)-DOI hydrochloride, ≥98% (HPLC), solid
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• drug control: Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada
• Farbe: white to off-white
• Löslichkeit: H₂O: 10 mg/mL; ethanol: 2 mg/mL
• SMILES String: NC(C)CC1=CC(OC)=C(I)C=C1OC.Cl
• InChI: 1S/C11H16INO2.ClH/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2;/h5-7H,4,13H2,1-3H3;1H
• InChIKey: QVFDMWGKHUFODK-UHFFFAOYSA-N
• Angaben zum Gen: human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Beschreibung

Biochem./physiol. Wirkung

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves